Also check the Hotel Del Sol. It's an updated motel, very cheerful, run by a well-respected hotel gr

We're considering going to San Francisco for spring break (mid-March), so I'm looking for a hotel recommendation. We need a room with three beds - one can be a sofa bed. This is my husband and myself, our son, and our daughter. We usually stay at Embassy Suites, Homewood Suites, air travel Residence Inn, etc, but I'm not seeing those as I look at SF choices. Not sure yet about which neighborhood to stay in, so all suggestions are welcome. We would like to be close to public transportation. Thanks.
There was a poster, of not so great repute, who long ago used to advocate the Cow Hollow Motor Inn and Suites. Then I believe another poster, of much greater repute, did in fact stay at that place, and reported it was good.
Cow Hollow Suites would be a much better choice than the suites hotels nearer the airport. BART is a 30-minute trip each way from the airport into the city, and the trip is not inexpensive - better to put that money toward a hotel room in the city.
If you're staying more than four or five days, maybe try VRBO or Homeaway? You could possibly find a condo or apartment for the same price as a hotel, and having a kitchen is great for saving a little money (breakfasts, snacks, etc) plus a bit more room for four people.
I know nothing about this place - I found it by searching on Expedia for a room for random dates for 2 adults air travel and 3 children (I know you have two, but I figured air travel putting in 3 would mean they'd air travel have to have 3 beds).
Also check the Hotel Del Sol. It's an updated motel, very cheerful, run by a well-respected hotel group, and in a terrific neighborhood for restaurants, shopping, people-watching. They have some suites.
Although I have personally not stayed at the Cow Hollow, friends have stayed there and like it. There is a great steakhouse near the Cow Hollow called Izzy's~the creamed spinach is fabulous (and I hate cooked spinach).
The Cow Hollow and/or Columbus are both great for families. However because they are fairly unique (decent quality, parking, family rooms) - they book up well in advance. Extremely high occupancy rates. So book them as soon as your dates are firm - especially for holiday periods like Spring break.
I just looked at the Fairmont GS. It looks fantastic, but the larger suite is out of my price range. I don't mind paying $300 or $350 in the city, but more than that for four nights would get pretty expensive. I'll look at the other suggestions next.